Vacancy Details: Bioinformatician - Core Bioinformatics Group

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Earlham Institute

Earlham Institute is a vibrant, contemporary research institute and registered charity, working in an area of rapid technological development and innovation.

Earlham Institute is strategically funded by the BBSRC to lead the development of a skill base in bioinformatics and a genomics technology platform for UK bioscience. The Institute is located on the Norwich Research Park, together with its partners: the John Innes Centre, the Institute of Food Research, The Sainsbury Laboratory, the University of East Anglia and the Norfolk and Norwich University Hospital. The research park has an excellent reputation for research in plant and microbial sciences, interdisciplinary environmental science and food, diet and health, to which Earlham Institute contributes strengths in genomics and bioinformatics. Close links exist between the NRP partners and new opportunities for collaboration in exciting new initiatives are under development. The NRP recently received £26M of government investment to facilitate innovation and further develop infrastructure to attract science and technology companies to the Park to enhance the vibrant environment and realise economic impact from research investment.

Earlham Institute is a UK hub for innovative Bioinformatics through research, analysis and interpretation of multiple, complex data sets. It hosts one of the largest computing hardware facilities dedicated to life science research in Europe. This has been boosted recently by an e-Infrastructure grant to expand the data storage capacity to a multi-petabyte unit, deploying a high performance cluster and large-memory server enabling the allocation of processes requiring several terabytes of computing memory.

Earlham Institute’s state of the art DNA sequencing facility operates multiple complementary technologies for data generation that provide the foundation for analyses furthering our fundamental understanding of genomes and how they function. We aim to be at the forefront of technological advances and are developing and implementing technologies to generate and analyse new types of data. We also develop novel platforms to provide access to computational tools and processing capacity for multiple academic and industrial users and promoting applications of computational bioscience. Earlham Institute has one fully owned subsidiary, Genome Enterprise Ltd (GEL) via which it offers genomic and bioinformatics services on a trading basis and works with commercial providers on a partnership basis. Earlham Institute also receives specific funding to enable knowledge exchange programmes which are supported across the institute teams.

disability confident employer

Advancing gender equality in science, engineering and technology.

Post Number1003273
Job TitleBioinformatician - Core Bioinformatics Group
Closing Date30 Jul 2017
GradeSC6
Starting Salary£30,750 - £37,750
Hours per week 37
Expected/Ideal Start Date 14 Aug 2017
Months Duration 36
Main purpose of the job The Earlham Institute (EI, Norwich, UK) is looking for a highly motivated bioinformatician to join our Core Bioinformatics Group to deliver high-quality data analysis pipelines that support the Institute’s Core Strategic Programmes and National Capability in Genomics and Single Cell analysis (NCGS). This role will have primary responsibility for building and maintaining computational workflows that assure timely and accurate processing of sequencing data from EI’s numerous and varied sequencing platforms. The post-holder will work alongside members of our genomics and project management teams to develop and implement quality assurance metrics, increase automation of tasks and assess new sequencing applications. The role will also involve working on a wide variety of bioinformatics projects in conjunction with our internal science faculty as well as external customers and collaborators. Projects will range in scale, type and complexity, from variant calling analyses on model organisms, to custom differential expression analyses, or de novo genome assembly and annotation of complex non-model organisms. The role will also involve building, extending and automating pipelines, where possible, to increase capability for delivering future projects.
Group Details The Core Bioinformatics Group at Earlham provides high quality computational analyses of a range of sequence data types and develops software and analysis pipelines that support the Institute’s Core Strategic Programmes and National Capability in Genomics and Single Cell Analysis (NCGS). The National Capability provides access to state of the art genomics technologies for research groups throughout the UK as well as delivering sequencing and genomics services to the associated Science Faculty groups and commercial customers. The Core Bioinformatics Group develops pipelines for the processing of raw sequence data from a wide variety of NGS platforms and works alongside Earlham research groups to establish new software tools and analysis methods.
Advert Text The Earlham Institute (EI, Norwich, UK) is looking for a highly motivated bioinformatician to join our Core Bioinformatics Group to deliver high-quality data analysis pipelines that support the Institute’s Core Strategic Programmes and National Capability in Genomics and Single Cell analysis (NCGS).

The role:

This role will have primary responsibility for building and maintaining computational workflows that assure timely and accurate processing of sequencing data from EI’s numerous and varied sequencing platforms. The post-holder will work alongside members of our genomics and project management teams to develop and implement quality assurance metrics, increase automation of tasks and assess new sequencing applications.

The role will also involve working on a wide variety of bioinformatics projects in conjunction with our internal science faculty as well as external customers and collaborators. Projects will range in scale, type and complexity, from variant calling analyses on model organisms, to custom differential expression analyses, or de novo genome assembly and annotation of complex non-model organisms. The role will also involve building, extending and automating pipelines, where possible, to increase capability for delivering future projects.

Required qualifications and experience:

The ideal candidate will possess an MSc or higher in bioinformatics or computer science, or have substantial relevant experience.

The postholder will have demonstrated experience of developing production quality software, and the ability to work and develop code as part of a team. They will also possess a high level of skills and experience of Perl, Python and Bash scripting, including the ability to interpret legacy code. The ideal candidate will also have demonstrable experience of successful project management.

Additional information:

Salary on appointment will be within the range £30,750 to £37,750 per annum depending on qualifications and experience. This is a full time post with a contract of three years.

As a Disability Confident employer, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy.

The closing date for applications will be 30th July 2017.
Key relationships INTERNAL: Reporting to the group leader, and interacting on a daily basis with members of the Core Bioinformatics Group as well as the Genomic Pipelines Group, EI’s Science Faculty and research teams. EI’s Deputy Directors and Director.
EXTERNAL: Visitors to EI, Collaborators, potential employees, Health and Safety co-ordinators, Training and Outreach Contacts. BBSRC and other stakeholders.
Main Activities & ResponsibilitiesPercentage
Ensuring sequencing data is correctly extracted, processed and analysed from our sequencing platforms.30
Pipeline workflow programming to deliver primary and secondary analysis pipelines.30
Participate in the design, implementation and testing of the quality control and analysis systems.10
Perform bespoke data analysis, such as de novo genome assembly, variant calling, annotation, differential expression analysis and taxanomic classification of metagenomic data.10
Work alongside our project management and lab teams to ensure data is processed according to project requirements. 5
Keep up-to-date with the latest bioinformatics tools and sequencing technologies.5
Follow prescribed practices for software version control, documentation, testing, and release engineering.5
Present technical and analytical status in weekly meetings and contribute to publications.5

Education & QualificationsRequirementImportance
Hold an MSc or higher in bioinformatics or computer science, or have relevant experience.Essential

Specialist Knowledge & SkillsRequirementImportance
Have a high level of skill and experience of Perl, Python and Bash scripting, including the ability to interpret legacy code.Essential
Have demonstrated experience of developing production quality software, with the ability to work and develop code as part of a team.Essential
Experience with processing and analysis of sequencing data.Essential
Have experience using High Performance Computing (HPC) resources and job scheduling systemsDesirable
Knowledge of the software and algorithms for sequence alignment, genome annotation, genome and transcriptome assembly, phylogenetic tree reconstruction and functional annotationDesirable
Experience with Pipeline workflow programmingDesirable

Relevant ExperienceRequirementImportance
Have a good understanding of the Next Generation Sequencing Technologies.Essential
Have a keen eye for detail, can identify potential problems before they happen and be a good problem solver.Essential
Apply analytical skills and creativity to solve diverse and challenging problems.Essential
Preparation of manuscripts for publication and the delivery of presentations to internal and external audiences.Desirable

Management and LeadershipRequirementImportance
Demonstrable experience of sucessful project managementEssential

Interpersonal & Communication SkillsRequirementImportance
Have strong team working and communication skills.Essential
Demonstrated ability to work independently, using initiative and applying problem solving skillsEssential
Ability to follow instructions/Standard Operating Procedures when requiredEssential
Excellent time management and organisational skills.Essential
Open to collaboration and willing to train others when requiredEssential
Be a good multi-tasker.Essential
An interest in outreach activities and communication of science to wider audiences Desirable

Additional RequirementsRequirementImportance
Promotes equality and values diversityEssential
Willingness to embrace the expected values and behaviours of all staff at the Institute, ensuring it is a great place to workEssential
Able to present a positive image of self and the Institute, promoting both the international reputation and public engagement aims of the InstituteEssential
Willingness to work outside standard working hours when requiredEssential
Ability to undertake occasional travel (national and international) related to collaborations and/or seminarsEssential