Vacancy Details: Postdoctoral Researcher - Wheat Transcriptomics and Epigenomics

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Earlham Institute

Earlham Institute is a vibrant, contemporary research institute and registered charity, working in an area of rapid technological development and innovation.

Earlham Institute is strategically funded by the BBSRC to lead the development of a skill base in bioinformatics and a genomics technology platform for UK bioscience. The Institute is located on the Norwich Research Park, together with its partners: the John Innes Centre, the Institute of Food Research, The Sainsbury Laboratory, the University of East Anglia and the Norfolk and Norwich University Hospital. The research park has an excellent reputation for research in plant and microbial sciences, interdisciplinary environmental science and food, diet and health, to which Earlham Institute contributes strengths in genomics and bioinformatics. Close links exist between the NRP partners and new opportunities for collaboration in exciting new initiatives are under development. The NRP recently received £26M of government investment to facilitate innovation and further develop infrastructure to attract science and technology companies to the Park to enhance the vibrant environment and realise economic impact from research investment.

Earlham Institute is a UK hub for innovative Bioinformatics through research, analysis and interpretation of multiple, complex data sets. It hosts one of the largest computing hardware facilities dedicated to life science research in Europe. This has been boosted recently by an e-Infrastructure grant to expand the data storage capacity to a multi-petabyte unit, deploying a high performance cluster and large-memory server enabling the allocation of processes requiring several terabytes of computing memory.

Earlham Institute’s state of the art DNA sequencing facility operates multiple complementary technologies for data generation that provide the foundation for analyses furthering our fundamental understanding of genomes and how they function. We aim to be at the forefront of technological advances and are developing and implementing technologies to generate and analyse new types of data. We also develop novel platforms to provide access to computational tools and processing capacity for multiple academic and industrial users and promoting applications of computational bioscience. Earlham Institute has one fully owned subsidiary, Genome Enterprise Ltd (GEL) via which it offers genomic and bioinformatics services on a trading basis and works with commercial providers on a partnership basis. Earlham Institute also receives specific funding to enable knowledge exchange programmes which are supported across the institute teams.

disability confident employer

Advancing gender equality in science, engineering and technology.

Post Number1003285
Job TitlePostdoctoral Researcher - Wheat Transcriptomics and Epigenomics
Closing Date15 Sep 2017
Gradesc6
Starting Salary£30,750 - £37,750
Hours per week 37
Project Title Postdoctoral Researcher - Wheat Transcriptomics and Epigenomics
Expected/Ideal Start Date 02 Oct 2017
Months Duration 36
Main purpose of the job The post holder will be responsible for conducting bioinformatics analyses associated with the project. Data generated from this study will be used to characterize regulatory regions in bread wheat and their importance for traits of interest such as spikelet growth and resistance to pathogens.
Department Organisms and Ecosystems
Group Details The Haerty Group is looking for an enthusiastic and motivated postdoctoral researcher to work on a large scale BBSRC funded project to integrate epigenomic, transcriptomics and genomics data to characterise regulatory regions associated with traits of interest (resistance, growth) in bread wheat. The Haerty group uses comparative genomics and transcriptomes of model and non-model species to characterize functional sequences, study their evolution within and between species and investigate the impact of mutations within these regions on traits and disease.
Advert Text Postdoctoral Researcher – Wheat Transcriptomics and Epigenomics


Applications are invited for a Postdoctoral Researcher to join the Laboratory of Wilfried Haerty in the Organisms and Ecosystems Group at the Earlham Institute


Background:


The Haerty Group is looking for an enthusiastic and motivated postdoctoral researcher to work on a large scale BBSRC funded project to integrate epigenomic, transcriptomics and genomics data to characterise regulatory regions associated with traits of interest (resistance, growth) in bread wheat. The Haerty group uses comparative genomics and transcriptomes of model and non-model species to characterize functional sequences, study their evolution within and between species and investigate the impact of mutations within these regions on traits and disease.


The role:


The post holder will be responsible for conducting bioinformatics analyses associated with the project. Data generated (RNA-Seq, small RNA-Seq, methylation, ChIP-Seq) from this study will be used to characterize regulatory regions in bread wheat and their importance for traits of interest such as spikelet growth and resistance to pathogens. The post holder will be required to work with relevant EI staff and with outside collaborators to carry out necessary research to meet key deliverables for the project. The post holder may also serve as a key technical resource to clarify issues, participate in analysis, and apply comprehensive knowledge to contribute to the completion of other research projects in the Haerty group.


The ideal candidate:


The successful applicant will ideally have a PhD in bioinformatics or population genomics or a related subject with experience of working on epigenomics and transcriptomics data and bioinformatics. Experience with NGS analysis (RNA-Seq, ChIP Seq) as well as scripting (PERL / Python) is essential. Experience with working on plant genomics clinical or low-input samples is highly desirable.


Additional information:


Salary on appointment will be within the range £30,750 to £37,750 per annum depending on qualifications and experience. This post is for a contract of three years.


For further information and details of how to apply, please visit our web site http://jobs.earlham.ac.uk/ or contact Human Resources, Norwich BioScience Institutes Partnership, Norwich Research Park, Colney, Norwich, NR4 7UH, UK, 01603 450462 quoting reference 1003285.


As a Disability Confident employer, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy.


The closing date for applications will be 15th September 2017.
Key relationships Internal: Willfried Haerty and members of the Haerty group.
External: Collaborators, funders, scientists in academic and commercial institutions in the UK and internationally.
Main Activities & ResponsibilitiesPercentage
Develop bioinformatics pipelines for the integration of the data generated as part of the project, carry the analyses and interpretations of the results to meet the objectives of the project. 50
Collaborate with colleagues within the EI as well as external collaborators in the development of original and world class research, including contributing to research proposals and grant applications 15
Prepare results, reports and manuscripts for publication in leading scientific journals and other relevant media 10
Disseminate research findings through presentations to various audiences at internal, national and international meetings. 5
Serve as a key technical resource to clarify issues, participate in analysis, and apply comprehensive knowledge to contribute to the completion of assignments as part of several research projects.5
Continually strive for excellence, seeking out and acting on feedback and relevant learning and development opportunities 5
Ensure research and record keeping is carried out in accordance with good practice, scientific integrity and compliance with local policies and any legal requirements 5
As agreed with the line manager, any other duties commensurate with the nature of the post such as supervision and training or contributing to the work of Institute committees 5

Education & QualificationsRequirementImportance
Biological sciences degree or similar or equivalent experience in genomics and transcriptomics Essential
PhD in bioinformatics, population genetics or related subject with experience of working on genomics and transcriptomics data and bioinformaticsEssential

Specialist Knowledge & SkillsRequirementImportance
Transcriptomics, genomics or epigenomics analysesEssential
Excellent problem solving skills with the ability to solve problems with numerous and complex variables Essential
StatisticsEssential
Excellent record-keeping and time management skills to work on several different projects at the same time Essential
Bioinformatics – working knowledge of programming languages including Perl, R, Linux and/or Python Essential
Population genetics and evolutionary biology Desirable
Working experience of population genomicsDesirable

Relevant ExperienceRequirementImportance
Experience in genomics, transcriptomics, epigenomics projects Essential
Experience with next generation sequencing and analysisEssential
Experience of working on externally funded projectsDesirable

Interpersonal & Communication SkillsRequirementImportance
Ability to follow instructions/Standard Operating ProceduresEssential
Promotes and strives for continuous improvementEssential
Excellent interpersonal and communication skills Essential
Good organizational skills Essential
Able to communicate with an interdisciplinary group including data analysts, computer scientists, proteomics specialists, and biologists Essential
Ability to work well with other members of a team Essential
Excellent oral and written skills Essential
Evidence of presenting research findings to internal and external audiencesDesirable
Networking and influencing skills and the ability to build effective collaborative linksDesirable

Additional RequirementsRequirementImportance
Promotes equality and values diversityEssential
Ability to maintain confidentiality and security of information where appropriateEssential
Willingness to embrace the expected values and behaviours of all staff at the Institute, ensuring it is a great place to workEssential
Able to present a positive image of self and the Institute, promoting both the international reputation and public engagement aims of the InstituteEssential