Vacancy Details: DNA Foundry, Science and Technology Lead

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Earlham Institute

Earlham Institute is a vibrant, contemporary research institute and registered charity, working in an area of rapid technological development and innovation.

Earlham Institute is strategically funded by the BBSRC to lead the development of a skill base in bioinformatics and a genomics technology platform for UK bioscience. The Institute is located on the Norwich Research Park, together with its partners: the John Innes Centre, the Institute of Food Research, The Sainsbury Laboratory, the University of East Anglia and the Norfolk and Norwich University Hospital. The research park has an excellent reputation for research in plant and microbial sciences, interdisciplinary environmental science and food, diet and health, to which Earlham Institute contributes strengths in genomics and bioinformatics. Close links exist between the NRP partners and new opportunities for collaboration in exciting new initiatives are under development. The NRP recently received £26M of government investment to facilitate innovation and further develop infrastructure to attract science and technology companies to the Park to enhance the vibrant environment and realise economic impact from research investment.

Earlham Institute is a UK hub for innovative Bioinformatics through research, analysis and interpretation of multiple, complex data sets. It hosts one of the largest computing hardware facilities dedicated to life science research in Europe. This has been boosted recently by an e-Infrastructure grant to expand the data storage capacity to a multi-petabyte unit, deploying a high performance cluster and large-memory server enabling the allocation of processes requiring several terabytes of computing memory.

Earlham Institute’s state of the art DNA sequencing facility operates multiple complementary technologies for data generation that provide the foundation for analyses furthering our fundamental understanding of genomes and how they function. We aim to be at the forefront of technological advances and are developing and implementing technologies to generate and analyse new types of data. We also develop novel platforms to provide access to computational tools and processing capacity for multiple academic and industrial users and promoting applications of computational bioscience. Earlham Institute has one fully owned subsidiary, Genome Enterprise Ltd (GEL) via which it offers genomic and bioinformatics services on a trading basis and works with commercial providers on a partnership basis. Earlham Institute also receives specific funding to enable knowledge exchange programmes which are supported across the institute teams.

disability confident employer

Advancing gender equality in science, engineering and technology.

Post Number1003291
Job TitleDNA Foundry, Science and Technology Lead
Closing Date9 Aug 2017
GradeSC5
Starting Salary£38,520 - £47,080
Hours per week 37
Expected/Ideal Start Date 04 Sep 2017
Months Duration 36
Main purpose of the job The post holder will establish and manage synthetic biology workflows at the Earlham DNA Foundry. This will include working with automation specialists and technical assistants to develop and execute protocols in DNA assembly, biosynthesis and genome engineering. In addition, they will engage and communicate with researchers in academia and industry to promote the mission of the Earlham Foundry and to establish and develop new collaborations.
Department Engineering Biology
Group Details The Earlham DNA Foundry is part of the UK National Capability in Genomics. Using start-of-the-art laboratory automation and synthetic biology approaches, the Foundry has automated nanoscale pipelines for (i) part-based assembly and bacterial transformation, (ii) quality control of assemblies and (iii) delivery of constructs to chassis organisms. The mission of the Foundry is to bring these capabilities to bear on research in academic in Industry.
Advert Text DNA Foundry, Science and Technology Lead

Applications are invited for a DNA Foundry, Science and Technology Lead to join the Engineering Biology Group at the Earlham Institute.

Background:

The Earlham DNA Foundry is part of the UK National Capability in Genomics and Single Cell. Using start-of-the-art laboratory automation and synthetic biology approaches, the Foundry has automated nanoscale pipelines for (i) part-based assembly and bacterial transformation, (ii) quality control of assemblies and (iii) delivery of constructs to chassis organisms. The mission of the Foundry is to bring these capabilities to bear on research in academic in Industry.

The role:

The post holder will establish and manage synthetic biology workflows at the Earlham DNA Foundry. This will include working with automation specialists and technical assistants to develop and execute protocols in DNA assembly, biosynthesis and genome engineering. In addition, they will engage and communicate with researchers in academia and industry to promote the mission of the Earlham Foundry and to establish and develop new collaborations.

The ideal candidate:

The ideal candidate will possess a PhD in Molecular Biology, Biotechnology, Synthetic Biology or a related subject. They will have an indepth understanding of molecular biology laboratory techniques, such as molecular cloning and purification of DNA. The postholder will have experience of collaborating with internal and external stakeholders on large scale projects. They will possess excellent communication and interpersonal skills.

Additional information:

Salary on appointment will be within the range £38,520 to £47,080 per annum depending on qualifications and experience. This post is for a contract of three years.

For further information and details of how to apply, please visit our web site http://jobs.earlham.ac.uk/ or contact Human Resources, Norwich BioScience Institutes Partnership, Norwich Research Park, Colney, Norwich, NR4 7UH, UK, 01603 450462 quoting reference 1003291.

As a Disability Confident employer, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy.

The closing date for applications will be 9th August 2017
Key relationships INTERNAL: Group Leader, EI’s Deputy Directors, Director and Senior Management Team. EI’s Science Faculty and Research Teams.
EXTERNAL: Collaborators, conference attendees, BBSRC and other key stakeholders, Senior visitors to EI.
Main Activities & ResponsibilitiesPercentage
Lead the establishment, management and delivery of synthetic biology workflows at the Earlham DNA Foundry30
Develop a business plan for the sustainability of the Foundry15
Assist with the development of research proposals15
Work collaboratively with automation specialists and technical assistants to develop and execute protocols in DNA assembly, biosynthesis and genome engineering15
Proactively engage and communicate with academia and industry to promote the capabilities of the Earlham Foundry and to establish new collaborations15
As agreed with line manager, any other duties commensurate with the nature of the role10

Education & QualificationsRequirementImportance
PhD in Molecular Biology, Biotechnology, Synthetic Biology or a related subjectEssential

Specialist Knowledge & SkillsRequirementImportance
Indepth understanding of molecular biology laboratory techniques including molecular cloning, purification of DNA, transfection and transformation, gene-expression analysis, genotyping etcEssential
Knowledge of genome engineering technologies including RNA guided CAS9Desirable
Knowledge of parallel DNA assembly technologies such as Golden Gate and Gibson AssemblyDesirable
Knowledge of methods used to deliver DNA to bacteria and eukaryotic cells (yeast, mammalian, plant)Desirable

Relevant ExperienceRequirementImportance
Experience of collaborating with industry/stakeholders and/or involvement in collaborative projectsEssential
Experience in molecular/synethic biology or biotechnology in any system (e.g. microbes, plants, yeasts, mammals) with evidence from publicationsEssential
Experience with heterologous gene expression techniques, e.g. monitoring gene expression and cell growthEssential
Experience with large scale projects and high-throughput approachesEssential
Experience in scaling-up or automating molecular biology laboratory protocolsEssential
Experience in project management and reporting to internal and external stakeholdersDesirable
Experience with synthetic biology approaches and techniques, including parallel DNA assembly, standardisation and modularisationDesirable
Have participated in iGEM (as team member, advisor or instructor)Desirable
Experience analysing NextGen sequencing dataDesirable
Experience with combinatorial biosynthesis of natural products in bacteria, yeast or plantsDesirable
Experience with laboratory management systems e.g. LIMSDesirable

Interpersonal & Communication SkillsRequirementImportance
Demonstrated ability to work independently, using initiative and applying problem solving skillsEssential
Ability to collaborate with internal and external stakeholdersEssential
Excellent oral and written communication skillsEssential
Excellent interpersonal skills with the ability to work as part of a teamEssential
Ability to prioritise and meet the demands of the groupEssential
Promotes and strives for continuous improvementEssential
Excellent time management and organisation skillsEssential

Additional RequirementsRequirementImportance
Promotes equality and values diversityEssential
Ability to undertake occasional travel (national and international) related to collaborations and seminarsEssential
Willingness to embrace the expected values and behaviours of all staff at the Institute, ensuring it is a great place to workEssential
Able to present a positive image of self and the Institute, promoting both the international reputation and public engagement aims of the InstituteEssential
Ability to maintain confidentiality and security of information where appropriateEssential