- Job Title
- Postdoctoral Scientist (Bioinformatics)
- Post Number
- Closing Date
- 17 Dec 2018
- Starting Salary
- £31,250 - £38,100
- Hours per week
- Project Title
- Expected/Ideal Start Date
- 02 Jan 2019
- Months Duration
Main Purpose of the Job
This role is part of a DARPA-funded project to develop a system for rapid detection of biological pathogens from sequencing of air samples. The jobholder will be involved in analysing sequencing data, developing novel bioinformatics pipelines and contributing to software development.
Internal: Reporting to Richard Leggett (Group Leader), the post holder will work closely with other members of the group who are engaged in complimentary research. External: the post holder will work closely with collaborators at the Natural History Museum and at an engineering company involved in the project. There may also be interactions with DARPA staff in the USA.
Main Activities & Responsibilities
- Run bioinformatics tools and pipelines in order to analyse sequencing datasets.
- Create new analysis pipelines or adapt existing pipelines to the needs of the project.
- Develop software tools to perform new kinds of analysis.
- As agreed with the line manager, any other duties commensurate with the nature of the post such as supervision and training or contributing to the work of Institute committees.
- Prepare results, reports and manuscripts for publication in scientific journals and other relevant media.
- Disseminate research findings through presentations to audiences at internal, national and international meetings.
Education & Qualifications
- Degree in Biology, Computer Science, Engineering, Physics or a related discipline
- PhD in Computational Biology, Bioinformatics, Computing Science, Mathematics, Biology or a related discipline. Or comparable experience.
Specialist Knowledge & Skills
- Knowledge of a range of bioinformatics tools for sequence analysis, alignment and metagenomic classification
- Appreciation for the challenges inherent in metagenomic analyses
- Knowledge of one or more scripting language for the development of pipelines
- Basic understanding of bioinformatic algorithms for classification and alignment
- Understanding of the principles of nanopore sequencing
- Knowledge of programming in C or C++ or Java
- Experience of programming in Perl, Python, C, C++, Java
- Experience with the analysis of nanopore data
- Experience developing software tools
- Experience with the analysis of Illumina, MinION or PacBio sequence data
- Experience with the analysis of metagenomic sequence data
Interpersonal & Communication Skills
- Excellent communication skills, both written and oral, including the ability to present complex information with clarity
- Demonstrated ability to work independently, using initiative and applying problem solving skills
- Good interpersonal skills, with the ability to work as part of a team
- Good presentation skills
- Excellent time management and organisational skills
- Attention to detail
- Promotes equality and values diversity
Who We Are
Earlham Institute is a vibrant, contemporary research institute and registered charity, working in an area of rapid technological development and innovation.
Earlham Institute is strategically funded by the BBSRC to lead the development of a skill base in bioinformatics and a genomics technology platform for UK bioscience. The Institute is located on the Norwich Research Park, together with its partners: the John Innes Centre, the Institute of Food Research, The Sainsbury Laboratory, the University of East Anglia and the Norfolk and Norwich University Hospital. The research park has an excellent reputation for research in plant and microbial sciences, interdisciplinary environmental science and food, diet and health, to which Earlham Institute contributes strengths in genomics and bioinformatics. Close links exist between the NRP partners and new opportunities for collaboration in exciting new initiatives are under development. The NRP recently received £26M of government investment to facilitate innovation and further develop infrastructure to attract science and technology companies to the Park to enhance the vibrant environment and realise economic impact from research investment.
Earlham Institute is a UK hub for innovative Bioinformatics through research, analysis and interpretation of multiple, complex data sets. It hosts one of the largest computing hardware facilities dedicated to life science research in Europe. This has been boosted recently by an e-Infrastructure grant to expand the data storage capacity to a multi-petabyte unit, deploying a high performance cluster and large-memory server enabling the allocation of processes requiring several terabytes of computing memory.
Earlham Institute’s state of the art DNA sequencing facility operates multiple complementary technologies for data generation that provide the foundation for analyses furthering our fundamental understanding of genomes and how they function. We aim to be at the forefront of technological advances and are developing and implementing technologies to generate and analyse new types of data. We also develop novel platforms to provide access to computational tools and processing capacity for multiple academic and industrial users and promoting applications of computational bioscience. Earlham Institute has one fully owned subsidiary, Genome Enterprise Ltd (GEL) via which it offers genomic and bioinformatics services on a trading basis and works with commercial providers on a partnership basis. Earlham Institute also receives specific funding to enable knowledge exchange programmes which are supported across the institute teams.
The Technology Algorithms Group is focused primarily on two areas: 1) Evaluating new genomics technologies and developing bioinformatics enabling tools. 2) Algorithms for analysis and assembly of metagenomic data - often inspired by new technology developments.
A lot of our current work involves third generation long reads sequencing platforms (particularly nanopore) but we are also evaluating new protocols and developing new tools for short read technologies (e.g. 10x).
Applications are invited for an enthusiastic and motivated Postdoctoral Scientist to join the Technology Algorithms Group at the Earlham Institute, based in Norwich, UK.
About Earlham Institute:
The Earlham Institute (EI) is a research institute focused on exploring living systems by applying computational science and biotechnology to answer ambitious biological questions and generate enabling resources.
The Technology Algorithms Group is focused primarily on evaluating new genomics technologies and developing bioinformatics enabling tools, as well as developing algorithms for analysis and assembly of metagenomic data.
This role is part of an exciting new project to develop a system for rapid detection of human, animal and plant pathogens from nanopore sequencing of air samples. The jobholder will be involved in analysing sequencing data, developing novel bioinformatics pipelines and contributing to software development.
The ideal candidate:
The ideal candidate will possess a PhD in Computational Biology, Bioinformatics, Computing Science, Mathematics Biology or related disciplines (full award or expected within the next six months). They will have experience of carrying out bioinformatics analyses (particularly metagenomics) and will be a capable programmer. However, we still encourage applications from candidates who are strong programmers without necessarily having the bioinformatics experience, or from accomplished bioinformaticians wanting to improve their programming or scripting skills.
Salary on appointment will be within the range £31,250 to £38,100 per annum depending on qualifications and experience. This is a fulltime post for a period of 3 years.
For further information and details of how to apply, please visit our web site http://jobs.earlham.ac.uk/ or contact the Human Resources team on 01603 450462 or firstname.lastname@example.org quoting reference 1003572.
As a Disability Confident employer, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy.