Postdoctoral Research Scientist
Post Details
Job Title
Postdoctoral Research Scientist
Post Number
1004361
Closing Date
19 Dec 2022
Grade
SC6
Starting Salary
£33,050 - £40,750
Hours per week
37
Project Title
Investigate the circadian clock with cellular resolution across multiple species
Months Duration
36

Job Description

Main Purpose of the Job

Applications are invited for a Postdoctoral Research Scientist to join the Laboratory of Prof Anthony Hall at the Earlham Institute, based in Norwich, UK.

We are looking for a highly motivated Postdoctoral Research Scientist to develop experimental and bioinformatics pipelines that apply a cutting-edge spatial transcriptomics approach to investigate functional clock architecture at a single-cell resolution in Arabidopsis and wheat.

This exciting project will use the plant circadian clock as a model to investigate the interplay of complex regulatory networks across multiple cell types and determine how cell state affects the clock.

Key Relationships

Mechanism of management: Day-to-day workload management Anthony Hall, they will collaborate with James Locke at the SLUC and Iain Macaulay at the EI

Main Activities & Responsibilities

To develop spatial transcriptomic protocols for both Arabidopsis and wheat, specifically within the Iain Macaulay group
Supervision and support of visiting or collaborating students and scientists
To facilitate communication with and data integration to international public repositories
Write and edit reports for both internal use and publication
Isolation and analysis of clock mutants in wheat
Use comparative approaches to identify and characterise circadian clock regulated
networks in wheat
As agreed with line manager, any other duties commensurate with the nature of the role

Person Profile

Education & Qualifications

Requirement
Importance
PhD in a relevant subject or possess equivalent experience of working in molecular, cell or plant biology
Essential

Specialist Knowledge & Skills

Requirement
Importance
Practical knowledge of apply advanced molecular biology techniques
Essential
Practical knowledge of computational methods for transcriptomic analysis
Essential
Interest in spatial transcriptomics
Essential
Knowledge of plant biology
Desirable
Knowledge of microscopy/cell biology
Desirable

Relevant Experience

Requirement
Importance
Molecular biology
Essential
Experience with coding in either R or python
Essential
Working with wheat or a model plant in a research environment
Essential
Experience designing and implementing bioinformatic workflows from the command line
Essential
Circadian, cell or plant biology
Desirable
Experience in bioinformatics related to transcriptomic analyses
Desirable
Experience of working with large datasets
Desirable

Interpersonal & Communication Skills

Requirement
Importance
Excellent communication skills, both written and oral, including the ability to present complex information with clarity
Essential
Good interpersonal skills, with the ability to work as part of a team
Essential
To be able to communicate clearly with EI staff at all levels
Essential
Demonstrated ability to work independently, using initiative and applying problem solving skill
Essential
Excellent time management and organisational skills
Essential
Promotes and strives for continuous improvement
Essential

Additional Requirements

Requirement
Importance
Attention to detail
Essential
Promotes equality and values diversity
Essential
Ability to maintain confidentiality and security of information where appropriate
Essential
Willingness to embrace the expected values and behaviours of all staff at the Institute, ensuring it is a great place to work
Essential
Able to present a positive image of self and the Institute, promoting both the international reputation and public engagement aims of the Institute
Essential
Willingness to work outside standard working hours when required
Essential

Who We Are

Earlham Institute

About the Earlham Institute
The Earlham Institute is a hub of life science research, training, and innovation focused on understanding the natural world through the lens of genomics.

We are building a future where the biology of any organism can be understood by analysing its genome. Our mission is to decode the scale and complexity of living systems so we can understand, benefit from, and protect life on Earth.

The Earlham Institute is based on the Norwich Research Park and is one of eight institutes that receive strategic funding from the UKRI Biotechnology and Biological Science Research Council (BBSRC).

Our Science
Earlham Institute scientists specialise in developing and testing the latest tools and approaches needed to decode living systems and make predictions about biology.

We are home to state-of-the-art facilities and technology, creating a unique combination of expertise and infrastructure. We have dedicated laboratories for genome sequencing, single-cell analysis, engineering biology, and large-scale automation; as well as one of the largest supercomputing facilities for life science research in Europe. Our Advanced Training team also provides access to specialised scientific training to upskill the next generation of research and technical staff.

Our Culture
The Earlham Institute champions 'team science'. Our collegiate and innovative research environment comes with significant support, including a commitment to your professional development, research and administrative assistance, and opportunities to build collaborations with scientists and industry on the Norwich Research Park, across the UK, and internationally.

The Institute is also home to talented technical and operational staff, whose invaluable contributions enable our science to have the maximum impact. We aim to recognise, reward, and develop all staff and students so that every individual feels able to achieve their best with us.

We work hard to nurture an engaged and positive workplace, centred on core values that include openness, technical excellence, and collaboration. We attract staff from around the world who contribute to - and benefit from - an environment that enables them to deliver world-class science alongside a supportive and social community.

Further Information:

  • Our Vision and Mission
  • Our Strategy
  • Our Culture
  • Life at Earlham Institute
  • Department

    Organisms and Ecosystems

    Group Details

    Earlham Institute is a vibrant research institute with a strong skill base in genomics technologies and bioinformatics. We aim to deliver programmes leading to improved food security, advances in industrial biotechnology and improved human health and wellbeing.

    The Hall Group have worked on the plant circadian clock for twenty years and has established an international research profile in this area of work. The candidate will join a multi-disciplinary team from across the institute developing new spatial genomics approaches, at the forefront of cell genomics. They will use these novel approaches to analyse the circadian clock at a cellular resolution.

    The Locke group is investigating gene expression dynamics in microbial and plant systems. The group is interdisciplinary, combining physics, mathematics, biology and computer science researchers to understand the design principles of dynamic gene regulation.

    Living in Norfolk

    Advertisement

    Postdoctoral Research Scientist

    Applications are invited for a Postdoctoral Research Scientist to join the Laboratory of Prof Anthony Hall at the Earlham Institute, based in Norwich, UK. The position is also in collaboration with James Locke’s group at The Sainsbury Laboratory, Cambridge University. The role will fit within a larger cross-institute research programme.

    Background:

    Earlham Institute is a vibrant research institute with a strong skill base in genomics technologies and bioinformatics. Our vision is to build a future where the biology of any organism can be understood by analysing its genome.

    The Hall Group have worked on the plant circadian clock for twenty years and has established an international research profile in this area of work. The candidate will join a multi-disciplinary team from across the institute developing new spatial genomics approaches, at the forefront of cell genomics. They will use these novel approaches to analyse the circadian clock at a cellular resolution.

    The Locke group is investigating gene expression dynamics in microbial and plant systems. The group lab is interdisciplinary, combining physics, mathematics, biology and computer science for researchers to understand the design principles of dynamic gene regulation.

    The role:

    We are looking for a highly motivated Postdoctoral Research Scientist to develop experimental and bioinformatics pipelines that apply a cutting-edge spatial transcriptomics approach to investigate functional clock architecture at a single-cell resolution in Arabidopsis and wheat. This exciting project will use the plant circadian clock as a model to investigate the interplay of complex regulatory networks across multiple cell types and determine how cell state affects the clock.

    Duties will specifically include:

    •Working collaboratively across the Earlham Institute to develop spatial transcriptomic protocols for both Arabidopsis and wheat for analysing the circadian clock; specifically with the Iain Macaulay’s single-cell group.
    •Collaborate with Plant Cell Atlas.
    •Analyse complex transcriptional datasets and collaborate with the Locke group to develop mathematical models.
    •Using comparative approaches to investigate differences in circadian clock function between species.
    •Work in collaboration with the Earlham Institute Biofoundry to generate DAP-seq datasets to identify DNA targets for clock transcription factors and other critical regulatory transcriptional networks in wheat.
    In addition to this, the post holder will have the opportunity to co-supervise PhD students within the group.

    The ideal candidate:

    Applicants should possess a PhD in a biological science with experience in molecular biology, single-cell biology, or circadian biology. We are also looking for candidates with experience in applying computation biology and bioinformatic approaches during their research.

    The post holder will be a team player with a broad knowledge of plant molecular biology, plant genetics, basic statistics, and coding (e.g., expertise in R or python). Experience of working with large datasets and collaborating with other research groups across interdisciplinary research projects would be advantageous, as well as experience of working in an HPC environment.

    Additional information:

    Salary on appointment will be within the range £33,050 to £40,750 per annum depending on qualifications and experience.  This is a full-time post for a contract of 36 months.

    Interviews will be held on either 5 or 6 January 2023.

    As a Disability Confident employer, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy.

    The closing date for applications will be 19th December 2022.